Expression and significance of hypoxia-inducible factor-1α on synovium from collagen-induced arthritis |
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Authors: | DAI Chen-cheng DAI Lie ZHENG Dong-hui LI Hai-gang LIU Hai-jun |
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Institution: | 1.Division of Rheumatology and Immunology,2 Department of Pathology,The Second Affiliated Hospital,Sun Yat-sen University,Guangzhou 510120,China.E-mail: dailie2002@21cn.com |
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Abstract: | AIM: To investigate the role of hypoxia-inducible factor-1α (HIF-1α) in the pathogenesis of rheumatoid arthritis (RA).METHODS: The collagen-induced arthritis (CIA) model was set up in male Wistar rats.The arthritis activity indexes,pathological changes and expression of HIF-1α on synovium at different time were observed through HE and immunohistochemistry staining.The correlations of HIF-1α expression with arthritis activity indexes and pathological scores were analyzed.RESULTS: Cytoplasmic and nucleic HIF-1α expressions were found on both lining and sublining area of synovium.HIF-1α expression in synovium increased gradually with the prolonged disease course.Synovial HIF-1α expression correlated significantly with arthritis activity indexes,total pathological score,synovial hyperplasia score and angiogenesis score,but not with inflammation score.CONCLUSION: HIF-1α may play important roles in the pathogenesis of RA through inducing synovial hyperplasia and angiogenesis. |
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Keywords: | Arthritis rheumatoid Hypoxia-inducible factor-1 Synovial membrane |
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