Nucleostemin gene expression in human breast tumor tissues and its relation with clinical pathology |
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Authors: | CAI Zi-wei ZHENG Xue-zhi HU Jing |
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Institution: | 1.Department of Pathophysiology,Mudanjiang Medical College,Mudanjiang 157011,China;2.Department of Pathophysio-logy,Medical College of Shantou University,Shantou 515031,China.E-mail: caiziwei-mdj@163.com |
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Abstract: | AIM: To study the expression of nucleostemin (NS) gene in human breast tumor tissues and the relations of NS gene expression level with histological grades,histological types and TNM stages of the tumor.METHODS: Total RNA was isolated from human breast tumor tissue.The methods of electrophoresis and RT-PCR were used in measuring NS gene expression level,and the relations of NS gene expression level with histological grades,histological types and TNM stages of the tumor were analyzed.RESULTS: The results indicated that there was no NS gene expression detected in normal breast tissues,and NS gene expression in malignant breast tumor tissues (P<0.01) was higher than that in the benign breast tumor tissues.The higher histological grades of the breast cancer showed the stronger NS gene expression (P<0.01),the higher TNM stages of the breast cancer showed the stronger NS gene expression (P<0.01),and the level of NS gene expression had not correlation with the histological types (P>0.05).CONCLUSION: It is suggested that there is no relation of NS gene expression level with histological types of the breast cancer,but there is a marked correlation of NS gene expression level with the histological grades and TNM stages. |
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Keywords: | Breast neoplasms Genes nucleostemin Gene expression |
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