Relationship between bone mineral density and polymorphism of vitamin D receptor gene in postmenopausal women in Guangzhou |
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Authors: | WU Wen ZHI Xi-mei LI Dong-feng LIN Kai XU Ling YANG Yan-hong |
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Affiliation: | The Center of Osteoporosis, Guangdong Provincial Peoples Hospital, Guangzhou 510080, China. E-mail: wuwen1964@163.com |
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Abstract: | AIM:To investigate the prevalence of vitamin D receptor (VDR) gene polymorphism in Guangzhou postmenopausal women and to study the relationship between bone mineral density (BMD) and VDR gene polymorphism.METHODS:The genotype of VDR gene of 203 postmenopausal women in Guangzhou was detected by polymerase chain reaction-restriction fragment length polymorphism. BMD of lumbar spine, femoral neck, troch and Wards triangle were measured by dual-energy X-ray absorptiometry. RESULTS:The distribution of VDR in 203 subjects was BB genotype 17(8.3%), Bb 60(29.6%), bb(62.1%), respectively. The B allelic gene frequencies reached 23.05%. The distribution followed the Hardy-Weinberg equilibrium. The difference was found in lumbar spine BMD between bb and the other two genotypes (P<0.05), but no significant difference between Bb and BB genotype (P>0.05). There was no significant difference in BMD of the other region among three genotypes (P>0.05). CONCLUSION:Genotype of VDR is related to BMD, but there is no enough evidence to support genotype of VDR as a genetic marker in predicting the risk of developing osteoporosis in Guangzhou postmenopausal women. |
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Keywords: | Vitamin D receptor Gene polymorphism Bone mineral density |
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