Characteristics of ventricular electrophysiology in a right ventricular rapid pacing-induced canine heart failure model |
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Authors: | ZHOU Shu-xian WU Wei ZHANG Yu-ling LEI Juan ZHANG Xu-ming |
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Affiliation: | Division of Cardiology,Department of Internal Medicine,2nd Affiliated Hospital of Sun Yat-sen University,Guangzhou 510120,China |
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Abstract: | AIM: To research the characteristics of ventricular electrophysiology in right ventricular rapid pacing-induced congestive heart failure (CHF) dogs.METHODS: Dogs (n=16) were randomly divided into 2 groups: the control (n=7) and the CHF group (n=9) induced by rapid right ventricular pacing at 240 pulse·min-1 for 4 to 5 weeks.The electrophysiologic parameters were evaluated by the technique of standard electric stimulation and monophasic action potential (MAP) recording.RESULTS: (1) Ventricular effective refractory period (VERP),ventricular MAP duration (MAPD90),ventricular late repolarization duration (VLRD) and intra-ventricular conduction time (IVCT) were prolonged by 26% (P<0.01),43% (P<0.01),318% (P<0.05),and 19% (P<0.01),respectively in CHF group.(2)The ratio of VERP to MAPD90 (VERP/MAPD90) was decreased by 13% (P<0.05) in CHF group.(3) The dispersion of ventricular recovery time (VRT-D) was increased by 185% (P<0.01) in CHF group.(4) The ventricular fibrillation threshold (VFT) was decreased by 48% (P<0.01) in CHF group.CONCLUSION: The abnormal electrophysiological changes in the CHF condition may be contributing factors of lethal ventricular arrhythmias and sudden cardiac deaths in CHF. |
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Keywords: | Heart failure congestive Electrophysiology Action potentials Ventricular fibrillation Hemodynamics |
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