Effects of Shengmai San on oxidative damage in mentally stressed mice |
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| Authors: | GONG Mu-xin WANG Lei WANG Qian LI Yu-juan KONISHI Tetsuya |
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| Institution: | 1.School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China;2.Beijing University of Traditional Chinese Medicine, Beijing 100029, China;3.Department of Functional Food Science and Food Analysis Science, Niigata University of Pharmacy and Applied Life Sciences, Niitsu 956-8603, Japan. E-mail: gongmuxin@126.com |
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| Abstract: | AIM: To investigate the preventive effects of Shengmai San (SMS) on oxidative damage in mentally stressed mice.METHODS: An oxidative stress mouse model was established by moustache-removed. Protein carbonyl and thiobarbituric acid reactive substance (TBARS) formation were determined as the oxidative stress markers.RESULTS: (1)Moustache-cut was founded to significantly enhance the behavioral movements of mice, especially large movements (movement 2 and rearing). SMS pre-administration inhibited the accelerated movements. (2) Protein carbonyl was increased in brain, heart, liver and kidney. TBARS in liver and heart increased in the moustache-cut mice, but SMS pretreatment inhibited the increased protein carbonyl and TBARS.CONCLUSION: SMS has the preventive effects on oxidative damage induced by emotional stress. |
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| Keywords: | Shengmai San Oxidative injury Protein carbonyl Thiobarbituric acid reactive substances |
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