Changes of IFN-γ, IL-6 and TNF-α levels in rats with severe pneumonia |
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Authors: | CHEN Ye-min HUANG Wen-jie LI Sheng-li LIANG Kun |
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Affiliation: | Department of Respiratory Diseases, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China. E-mail: Huangyelu1029@VIP.163.com |
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Abstract: | AIM:To study the variety of cytokines in severe bacterial pneumonia of Sprague Dawleg (SD) rats. METHODS:A total of 60 SD rats were randomly divided into three groups: model Ⅰ group (n=24), model Ⅱ group (n=24), and control group (n=12). Rats in the model Ⅰ group and the model Ⅱ group were intratracheally instilled with suspension of klebsiella pneumoniae at different doses. Rats in the control group were intratracheally injected with 1 mL saline. On the 2nd, 4th and 6th day after intratracheal instillation, 1/3 rats in each group were killed to determine the concentration of IFN-γ, IL-6 and TNF-α in blood. RESULTS:The levels of IL-6 and TNF-α in model groups were higher than those in control group, while the level of IFN-γ was lower. The change of cytokines was more significant in the model Ⅱ group (severe pneumonia) than those in the model Ⅰ group. CONCLUSION:The cytokines we studied may play an important role in the pathogenesis of severe pneumonia. The change of cytokines is more significant in severe pneumonia than those in common pneumonia. |
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Keywords: | Pneumonia Klebsiella Interleukin-6 Tumor necrosis factor Interferon type Ⅱ |
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