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Effect of Ganoderma lucidum spores on IL-1β and c-Fos in the brain tissue of epilepsy rats
Authors:WANG Wei-qun  WANG Shu-qiu  LIU Yue-xia  MA Xiao-ru  YU Hai-bo  WANG Bai-xin  MENG De-xin  ZHANG Ming-liang
Institution:1.The Basic Medical College of Jiamusi University, Jiamusi 154007, China;2.Jiamusi Center Hospital, Jiamusi 154002, China. E-mail: wang_shuq@163.com
Abstract:AIM: To observe the influence of Ganoderma lucidum spores on the cytokine IL-1β and c-Fos in the brain tissue of epilepsy rats. METHODS: The IL-1β level was examined by radioimmunoassay and the c-Fos expression was measured by mmunohistochemical assay. RESULTS: Comparing the Ganoderma lucidum spores group with the epilepsy model group: c-Fos positive cell count in brain cortex and hippocampus in treatment group was obviously reduced. IL-1β level in brain tissue was also reduced obviously. CONCLUSION: Ganoderma lucidum spores effectively reduces cytokine IL-1β in brain tissue of epilepsy rats, improves the immunity dysfunction and plays a role in anti-epilepsy through suppressing c-Fos expression in epilepsy rats brain tissue and blocking of LRG.
Keywords:Ganoderma lucidum spores  Epilepsy  Interleukin-1  Protein  c-Fos  
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