Effect of Ganoderma lucidum spores on IL-1β and c-Fos in the brain tissue of epilepsy rats |
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Authors: | WANG Wei-qun WANG Shu-qiu LIU Yue-xia MA Xiao-ru YU Hai-bo WANG Bai-xin MENG De-xin ZHANG Ming-liang |
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Institution: | 1.The Basic Medical College of Jiamusi University, Jiamusi 154007, China;2.Jiamusi Center Hospital, Jiamusi 154002, China. E-mail: wang_shuq@163.com |
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Abstract: | AIM: To observe the influence of Ganoderma lucidum spores on the cytokine IL-1β and c-Fos in the brain tissue of epilepsy rats. METHODS: The IL-1β level was examined by radioimmunoassay and the c-Fos expression was measured by mmunohistochemical assay. RESULTS: Comparing the Ganoderma lucidum spores group with the epilepsy model group: c-Fos positive cell count in brain cortex and hippocampus in treatment group was obviously reduced. IL-1β level in brain tissue was also reduced obviously. CONCLUSION: Ganoderma lucidum spores effectively reduces cytokine IL-1β in brain tissue of epilepsy rats, improves the immunity dysfunction and plays a role in anti-epilepsy through suppressing c-Fos expression in epilepsy rats brain tissue and blocking of LRG. |
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Keywords: | Ganoderma lucidum spores Epilepsy Interleukin-1 Protein c-Fos |
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