| 头孢喹肟的体外抗炎作用 |
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| 引用本文： | 崔国有,慈鑫鑫,梅妹,邓旭明,陈建光.头孢喹肟的体外抗炎作用[J].中国兽医学报,2009,29(10). |
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| 作者姓名： | 崔国有 慈鑫鑫 梅妹 邓旭明 陈建光 |
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| 作者单位： | 1. 吉林大学,吉林,长春,130062
2. 北华大学,吉林,吉林市,132013 |
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| 摘 要： | 通过构建的细菌脂多糖(LPS)诱导小鼠巨噬细胞(RAW264.7)的体外炎症模型,研究了不同浓度头孢喹肟对肿瘤坏死因子(TNF-α),IL-1β,IL-6,IL-10和一氧化氮(NO)合成的影响,以及对NF-κB活性的影响.结果显示,1、5、10 mg/L的头孢喹肟能显著抑制RAW264.7合成的TNF-α、IL-1β、IL-6和NO,但是对IL-10无显著调节作用.头孢喹肟以剂量依赖的方式显著抑制了LPS对NF-κB的激活作用.结果表明,头孢喹肟可能通过NF-κB这条通路发挥抗芡作用.
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| 关 键 词： | 头孢喹肟 脂多糖 细胞因子 一氧化氮 NF-κB |
Anti-inflammatory effect and mechanism of cefquinome |
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| CUI Guo-you,CI Xin-xin,MEI Mei,DENG Xu-ming,CHEN Jian-guang.Anti-inflammatory effect and mechanism of cefquinome[J].Chinese Journal of Veterinary Science,2009,29(10). |
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| Authors: | CUI Guo-you CI Xin-xin MEI Mei DENG Xu-ming CHEN Jian-guang |
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| Abstract: | Through LPS-induced murine RAW264.7 macrophages in vitro,the effect of cefquinome was explored on the generation of cytokines involved in the inflammatory process, such as TNF, IL-1β, IL-6, IL-10, and NF-κB. The results showed that 1,5 and 10mg/L of cefquinome significantly decreased the production of TNF, 1L-1β,IL-6 and NO,but didn't have significant effect on IL-10. Signal transduction studies showed that cefquinome significantly inhibited p65-NF-κB in a dose-dependence manner. Accordingly,we concluded that cefquinome-induced attenuation of inflammatory cytokine production upon exposure to LPS was at least partially mediated by the suppression of NF-κB pathway. |
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| Keywords: | cefquinome LPS cytokine NO NF-κB |
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