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| 马传染性贫血病毒在慢性感染体内的抗原变异 | |
| 引用本文： | 王全凯,庞海,孔宪刚,杜锐. 马传染性贫血病毒在慢性感染体内的抗原变异[J]. 吉林农业大学学报, 2000, 22(3): 81-84 |
| 作者姓名： | 王全凯 庞海 孔宪刚 杜锐 |
| 作者单位： | 1. 吉林农业大学中药材学院,长春,130118 2. 东京大学,日本东京 3. 中国农业科学院哈尔滨兽医研究所,哈尔滨150001 |
| 基金项目： | 日本国际协力财团! (JICA，975 12 )，日本农林水产省家畜卫生试验场! (No 5 13)资助项目 |
| 摘 要： | 应用在日本发离的马传染性贫血病毒（ＥＩＡＶ）强毒株Ｐ３３７－Ｖ７０实验感染了１匹健康马，经２次感染后，这匹实验感染并未呈现临床症状。从这匹马的外周和肝组织获得了覆盖马传染性贫血病毒ｇｐ９０基因主要中和抗原功能区（ＰＮＤ）的前病毒序列。通过对这些序列的比较分析发现，一些序列在ＰＮＤ功能区含有核苷酸的插入变异。 |
| 关 键 词： | 马 传染性贫血病毒 gp90基因 核苷酸序列 |
| 修稿时间： | 2000-03-06 |
EIAV Variation in a Chronically Infected Horse |
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| WANG Quan-kai,PANG Hai,KONG Xian-gang,DU Rui. EIAV Variation in a Chronically Infected Horse[J]. Journal of Jilin Agricultural University, 2000, 22(3): 81-84 | |
| Authors: | WANG Quan-kai PANG Hai KONG Xian-gang DU Rui |
| Abstract: | The present experiment was designed to observe the genetic variation of equine infectious anemia virus (EIAV) envelope gp90 gene in infected horse One horse was experimentally infected twice with P337 V70 strain but did not show clinical signs. Proviral sequences covering principal neutralizing domain (PND) of EIAV gp90 gene were obtained from the buffy coat and liver of the horse through PCR amplification and cloning Comparative analysis of the sequences revealed that some sequences contained the nucleotide insertions in the PND region |
| Keywords: | equine infectious anemia virus gp90 gene provirus variation nucleotide sequence |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |