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A suspected case of ornithine transcarbamylase deficiency in a cat
Authors:Washizu Tsukimi  Washizu Makoto  Zhang Chunhua  Matsumoto Isamu  Sawamura Masaki  Suzuki Takashi
Affiliation:Department of Clinical Pathology, Nippon Veterinary and Animal Science University, Tokyo, Japan.
Abstract:An 18 month-old, intact female American Shorthair cat was presented for evaluation of stunted growth and postprandial depression. Fasting serum ammonia and serum bile acid concentrations were above reference ranges at 396 microg/dl and 6.5 micromol/ l and their postprandial concentrations were 785 microg/dl and 9.5 micromol/l, respectively. The initial tentative diagnosis of a portosystemic shunt was excluded by mesenteric portography and histopathology of the liver. The cat was then suspected of a urea cycle enzyme deficiency and its urine was analyzed by gas chromatography-mass spectrometry. A presumptive diagnosis of ornithine transcarbamylase deficiency was made on the basis of the detection of orotic acid and uracil.
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