| Bmi1基因与干细胞增殖和肿瘤发生研究进展 |
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| 引用本文： | 王平,庞全海,夏玉,张超,吴崇晖.Bmi1基因与干细胞增殖和肿瘤发生研究进展[J].动物医学进展,2012(6):122-125. |
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| 作者姓名： | 王平 庞全海 夏玉 张超 吴崇晖 |
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| 作者单位： | 山西农业大学动物科技学院 |
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| 基金项目： | 国家自然科学基金项目(30972223);山西农业大学基金(614144;412528) |
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| 摘 要： | 干细胞是一类具有自我更新能力并可向多种细胞、组织类型分化的细胞。Bmi1是PcG(poly-comb group)家族重要的调控基因,该基因与干细胞的增殖和肿瘤的发生密切相关,在维持干细胞的自我更新能力中起关键的作用。增强干细胞自我更新的能力可以改变干细胞的生物特性,继而导致肿瘤的发生。
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| 关 键 词： | 干细胞 Bmi1基因 肿瘤 |
Progress on Bmi1 Gene in Stem Cell Proliferation and Tumorigenesis |
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| WANG Ping,PANG Quan-hai,XIA Yu,ZHANG Chao,WU Chong-hui.Progress on Bmi1 Gene in Stem Cell Proliferation and Tumorigenesis[J].Progress In Veterinary Medicine,2012(6):122-125. |
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| Authors: | WANG Ping PANG Quan-hai XIA Yu ZHANG Chao WU Chong-hui |
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| Institution: | (College of Animal Science and Veterinary Medicine,Shanxi Agricultural University,Taigu,Shanxi,030801,China) |
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| Abstract: | Stem cells are a class of self-renewal cells,and can differentiate into a diverse range of specialized cell types.Bmi1,a polycomb group repressor,is tightly related to stem cell self-proliferation and may play a key role in tumorigenesis,has been determined to play critical roles in the self-renewal of stem cells.Enhanced the ability of stem cell self-renewal can change the biological properties of stem cells,and then leading to tumorigenesis. |
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| Keywords: | stem cell Bmi1 gene tumor |
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