Multiple myeloma in cats: variable presentation with different immunoglobulin isotypes in two cats |
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Authors: | Bienzle D Silverstein D C Chaffin K |
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Affiliation: | Department of Pathobiology, University of Guelph, ON, Canada. |
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Abstract: | Multiple myeloma was diagnosed in two cats with monoclonal hyperglobulinemia, proteinuria, and plasma cell proliferations in bone marrow. An immunoglobulin G-producing myeloma occurred in the vertebral bone marrow of one cat, and twice responded to surgical reduction followed by a combination of local irradiation and chemotherapy. The cat's survival time was approximately 2 years. The other myeloma in a cat that presented with hypercalcemia and renal insufficiency involved visceral organs and produced a biclonal peak due to immunoglobulin A dimer formation on serum electrophoresis. This cat's tumor did not respond to chemotherapy. |
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