透皮贴剂在兽药制剂领域的研究进展(英文)

随着药剂学与其他学科理论和先进技术的发展,许多新型给药系统在兽医临床的应用有逐步增加的趋势。在众多给药系统中,透皮贴剂通过皮肤敷贴给药后在体内长时间保持稳定有效的血药浓度和治疗作用,为一些慢性疾病和局部镇痛的治疗及预防提供了一种使用简单方便和安全有效的给药方式。国内外已积极开发兽药透皮制剂,并在试验应用中取得了满意效果。文章结合目前国内外兽药透皮贴剂的研究,系统阐述了透皮贴剂的发展现状与特点、影响透皮的因素及该剂型在兽药临床中的使用评价。

Research Progress of Transdermal Patches in Veterinary Drug Preparations

With the development of pharmaceutics and other disciplines theories and advanced technologies, the application of many new drug delivery systems has gradually increased in clinical veterinary. Among the many drug delivery systems, transdermal patch can maintain stable and effective plasma concentration and therapeutic effect in vivo for a long time after skin dressing delivery, which provides a safe and effective drug-delivery way for the therapy and prevention of some chronic diseases and partial analgesia in a simple and convenient way. Veterinary drug transdermal preparations have been developed both at home and abroad, and satisfactory results have been achieved in the experimental application. Based on the study of veterinary transdermal patches at home and abroad, this paper systematically describes the development and characteristics of transdermal patches, the factors affecting skin permeation and the evaluation this type of preparations in veterinary drugs.