Repeated Early Embryonic Loss in a Thoroughbred Mare with a Chromosomal Translocation [64,XX,t(2;13)] |
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Authors: | Teri L Lear Terje Raudsepp Judith M Lundquist Stuart E Brown |
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Institution: | 1. Department of Veterinary Science, Maxwell H. Gluck Equine Research Center, University of Kentucky, Lexington, KY;2. Department of Veterinary Integrated Biosciences, Texas A&M University, College Station, TX;3. Hagyard Equine Medical Institute, Lexington, KY |
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Abstract: | Peripheral blood samples from a 13-year-old Thoroughbred mare were submitted for chromosome analysis. The mare had a poor reproduction record only producing four live foals during her 10 years as a broodmare. She had remained barren or experienced early embryonic loss in the other 6 years. Chromosomal analysis revealed the mare carried a rare nonreciprocal translocation involving chromosomes 2 and 13 64,XX,t(2;13)]. Fluorescence in situ hybridization with probes specific for horse chromosomes 2 and 13 were used to confirm the nonreciprocal translocation. Both conventional and molecular cytogenetic techniques are important for identifying and characterizing chromosomal abnormalities in horses with poor reproductive performance, particularly in mares experiencing repeated early embryonic loss. |
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Keywords: | Horse Equine Chromosome Translocation Fertility Reproduction |
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