Proteomic Characterization of Equine Cerebrospinal Fluid |
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| Authors: | Carolyn J Broccardo Gisela Soboll Hussey Lutz Goehring Paul Lunn Jessica E Prenni |
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| Institution: | 1. Proteomics and Metabolomics Facility, Colorado State University, Fort Collins, CO;2. Department of Pathobiology and Diagnostic Investigation, Michigan State University, Lansing, MI;3. Department of Clinical Sciences, Colorado State University, Fort Collins, CO;4. College of Veterinary Medicine, North Carolina State University, Raleigh, NC |
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| Abstract: | Cerebrospinal fluid (CSF) is a biofluid that is reflective of overall health. Although proteomic profiling of human CSF has been performed in the context of a variety of disease states, this report represents the first comprehensive proteomic analysis of equine CSF. A total of 320 proteins were confidently identified across six healthy horses, and these proteins were further characterized by gene ontology terms mapped in UniProt, and normalized spectral abundance factors were calculated as a measure of relative abundance. Theses results provide an optimized protocol for analysis of equine CSF and lay the groundwork for future studies involving the study of equine CSF in the context of pathogenic disease states. |
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| Keywords: | Equine Cerebrospinal fluid Proteomics Normalized spectral abundance factor Gene ontology |
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