Anti-inflammatory homoisoflavonoids from the tuberous roots of Ophiopogon japonicus |
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Authors: | Li Ning Zhang Jia-Yu Zeng Ke-Wu Zhang Liang Che Yan-Yun Tu Peng-Fei |
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Affiliation: | State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, People's Republic of China. |
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Abstract: | Two new homoisoflavonoids, named ophiopogonone E (1) and ophiopogonanone H (2), together with thirteen known ones (3-15) were isolated from the tuberous roots of Ophiopogon japonicus. Their structures were elucidated by spectroscopic and chemical analyses. Compounds 7 and 15 were isolated from the genus for the first time. In addition, compounds 2-15 were evaluated for their effects on the inhibition of NO production induced by lipopolysaccharide in the murine microglial cell line BV-2. Compounds 2, 4, 6, 7, 10, 11 showed potent inhibitory effects on NO production with IC(50) values of 20.1, 17.0, 7.8, 5.1, 19.2 and 14.4 μM respectively. |
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Keywords: | Ophiopogon japonicus Homoisoflavonoids Anti-inflammatory Inhibitory effects of nitric oxide production Ophiopogonone E Ophiopogonanone H |
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