| GnRH依赖型性早熟遗传调控系统研究进展 |
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| 引用本文： | 韩威,李慧芳,朱云芬,宋迟,徐文娟. GnRH依赖型性早熟遗传调控系统研究进展[J]. 家畜生态学报, 2013, 34(1): 1-5 |
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| 作者姓名： | 韩威 李慧芳 朱云芬 宋迟 徐文娟 |
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| 作者单位： | 1.中国农业科学院家禽研究所，江苏扬州225125；2.南京农业大学，江苏南京210095 |
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| 基金项目： | 江苏省家禽科学研究所青年基金项目(JQ201006);现代农业产业技术体系建设专项资金;国家863计划项目(2011AA100305);国家自然科学基金项目(31201799) |
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| 摘 要： | 性早熟在人类上表现为病理状态,而在家禽生产上则是一个具有重要经济价值的性状。人类性早熟调控机理的研究较为透彻,尤其是近年来全基因关联分析方法的应用,使得研究者对于性成熟启动相关新基因发掘及其调控网络的认识更加深入。论文综述了人类Gn-RH依赖型性早熟(GDPP)的5个基因调控系统,包括kisspeptin系统、γ-GABA系统、NPY和leptin系统、LIN28B系统和NKB系统的研究进展,为禽类早熟性状研究提供依据。
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| 关 键 词： | 性早熟 基因突变 调控系统 |
| 收稿时间： | 2012-07-13 |
Research Progress of the Genetic Regulation System in GnRH-dependent Precocious Puberty |
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| HAN Wei,LI Hui-fang,ZHU Yun-fen,SONG Chi,XU Wen-juan. Research Progress of the Genetic Regulation System in GnRH-dependent Precocious Puberty[J]. Journal of Domestic Animal Ecology, 2013, 34(1): 1-5 |
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| Authors: | HAN Wei LI Hui-fang ZHU Yun-fen SONG Chi XU Wen-juan |
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| Affiliation: | 1. Poultry Institute, Chinese Academy of Agricultural Science, Yangzhou,Jiangsu 225125, China;2. Nanjing Agricultural University, Nanjing,Jiangsu 210095, China |
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| Abstract: | Precocious puberty performs as pathological condition in humans, but it is an important trait in animal production. The research of human precocious puberty regulation mechanism is more thorough, especially in recent years the genome wide association study method contributes to find more new genes and deeply understand the genetic networks. This paper summarized the progress of genetic systems in human GnRH dependent precocious puberty, including kisspeptin system, γ GABA system, NPY and leptin system, LIN28B system and NKB system. These could supply a basis for the relevant study in animals. |
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| Keywords: | precocious puberty gene mutation regulation system |
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