JAK-STAT信号通路研究进展

信号通路JAK-STAT参与机体多种调节反应,在细胞因子等与其相应受体结合后激活JAK激酶,进一步活化其下游信号蛋白分子STAT,导致STAT同源或异源二聚体化,随后二聚体蛋白移位核内,与相应的靶基因启动子结合,控制目的蛋白的表达,对机体的调控起着重要作用。

Advances in JAK-STAT Signaling Pathway

JAK-STAT signaling pathway involved in various of physiological and pathological responses.JAK kinases were activated after the binding of cytokines to their corresponding receptors,further phosphorylation of STATs were produced which result in homologous or heterologous dimerization,the dimeric protein then translocated into the nucleus and binding the promoters of relevant target genes for the controlling of expression of objective proteins.Consequently,the pathway plays an momentous role in the regulationg of organisms.