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JAK-STAT信号通路研究进展
引用本文:宋舟,张立艳,董海兵,白换力,陈伟,吴帅成,伊鹏霏,付本懂,申海清,韦旭斌.JAK-STAT信号通路研究进展[J].中国畜牧兽医,2012,39(6):128-132.
作者姓名:宋舟  张立艳  董海兵  白换力  陈伟  吴帅成  伊鹏霏  付本懂  申海清  韦旭斌
作者单位:吉林大学畜牧兽医学院,吉林长春 130062
基金项目:“十一五”国家科技支撑计划
摘    要:信号通路JAK-STAT参与机体多种调节反应,在细胞因子等与其相应受体结合后激活JAK激酶,进一步活化其下游信号蛋白分子STAT,导致STAT同源或异源二聚体化,随后二聚体蛋白移位核内,与相应的靶基因启动子结合,控制目的蛋白的表达,对机体的调控起着重要作用。

关 键 词:信号通路  JAK-STAT  转导  
收稿时间:2011-12-12

Advances in JAK-STAT Signaling Pathway
SONG Zhou , ZHANG Li-yan , DONG Hai-bing , BAI Huan-li , CHEN Wei , WU Shuai-cheng , YI Peng-fei , FU Ben-dong , SHEN Hai-qing , WEI Xu-bin.Advances in JAK-STAT Signaling Pathway[J].China Animal Husbandry & Veterinary Medicine,2012,39(6):128-132.
Authors:SONG Zhou  ZHANG Li-yan  DONG Hai-bing  BAI Huan-li  CHEN Wei  WU Shuai-cheng  YI Peng-fei  FU Ben-dong  SHEN Hai-qing  WEI Xu-bin
Institution:College of Animal Husbandry and Veterinary Medicine, Jilin University,Changchun 130062,China
Abstract:JAK-STAT signaling pathway involved in various of physiological and pathological responses.JAK kinases were activated after the binding of cytokines to their corresponding receptors,further phosphorylation of STATs were produced which result in homologous or heterologous dimerization,the dimeric protein then translocated into the nucleus and binding the promoters of relevant target genes for the controlling of expression of objective proteins.Consequently,the pathway plays an momentous role in the regulationg of organisms.
Keywords:signaling pathway  JAK-STAT  transduce
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