半乳糖凝集素1蛋白及其生物学功能

半乳糖凝集素1(Galectin-1)是一种分子质量约为14 ku的β-糖结合蛋白,是动物凝集素家族的成员之一。作为多种癌症的诊断指标,治疗癌症的新突破口,对Galectin-1的研究备受关注。此外,Galectin-1分布广泛,与多种正常生物功能相关,如细胞生长、神经修复、血管再生、软骨形成等。现阶段,关于Galectin-1在鹿茸再生中的研究很少,但鹿茸再生中许多过程与Galectin-1的功能高度相关。与肿瘤同样高速生长且高表达Galectin-1的鹿茸组织并不发生癌变,这可能对癌症的研究有所启发。为了寻找治疗癌症的新方法,解释鹿茸再生机制,了解Galectin-1蛋白在肿瘤和鹿茸中的功能研究进展至关重要,文章就其进行了综述。

Research Progress on Galectin-1 and its Biological Functions

Galectin-1,a molecular that has 14ku,is one of the lectin family members.Being used as a diagnostic index of various cancers,Galectin-1molecule has aroused wide interest as a new target molecule for the treatment of cancer.Besides,Galectin-1plays various normal biological functions,such as cell growth,nerve repair,revascularization and cartilage formation.To data,little research has been done about Galectin-1in the regeneration of deer antlers,although Galectin-1may be indispensible in the processes during antler regeneration based on its unique function.Compared to tumour,antlers also grow fast and highly express Galectin-1,but antler tissue does not become cancerous,which could inspire us for cancer research.To develop a new cancer therapy and solve the mystery of deer antler regeneration,it is important to learn about the biological functions of Galectin-1in both tumourogenesis and antler regeneration.