多拉菌素浇泼剂在犬体内的药代动力学

本试验对多拉菌素浇泼剂在犬血浆中的药代动力学进行了研究。犬背部皮肤一次浇注多拉菌素浇泼剂(0.1 mg/kg体重),给药后,不同时间点从犬前肢静脉采血。以高效液相色谱法对血浆中药物浓度进行测定,血浆药物浓度—时间数据用WinNonlin 5.2.1的非房室模型药动软件处理。给药后的主要药物动力学参数为:t1/2β为(2.14±0.56)d,T_max为(1.00±0.00) d,C_max为(24.38±4.82) ng/mL,AUC为(89.79±16.90)ng/(d·mL)。提示多拉菌素浇泼剂在犬体内血药浓度维持的时间较长,消除缓慢。

Pharmacokinetics of the Pour-on Preparation of Doramectin in Dogs

Pharmacokinetics studies of pour-on of doramectin in dog blood plasma. Drow blood from the jugular vein of the dogs in different time after used the pour-on of doramectin one time on the skin of back with the concentration 0.1 mg/kg·bw. We used the method of the HPLC to detect the concentration of the doramectin in the blood plasma. The blood plasma doramectin concentration and time data was processed by the non compartment analysis of the WinNonlin5.2.1 software. The main pharmacokinetic parameters were the maximum concentration (C_max) of the doramectin in the blood plasma is (24.38±4.82) ng/mL, and the time is (1.00±0.00) d (T_max)after we used the doramectin pour-on. The elimination half life (t1/2β) is (2.14±0.56) d. Area under curve (AUC) is (89.79±16.90) ng/(d·mL). The results showed that doramectin has a long persistence in the plasma concentrations and eliminated slowly in dogs.