干扰素制剂冻干技术研究进展

干扰素制剂具有广谱的抗病毒和免疫调节活性,在医学和兽医临床上具有广阔的应用前景。但在实际生产中,液体剂型干扰素制剂存在热稳定性差、不易长期保存和远距离运输等问题,冻干后则可延长保存期、增加稳定性。作者主要对冻干技术的原理、干扰素冻干保护剂和冻干工艺的筛选等进行了综述。

Research Progress on Interferon Freeze-drying Technology

Interferon products, with the broad-spectrum antiviral and immunomodulatory activity, have broad application prospects in the field of medicine and clinical veterinary medicine. In the actual practice, liquid dosage form of interferon preparations has the problems of poor thermal stability, difficult long-term preservation, long-distance transportation, et al. However, the shelf life and stability of the lyophilized interferon preparations could be increased. In this paper, the principle of freeze-drying technology, screening of lyoprotectant and freeze-dried process for interferon products are reviewed.