| 舌癌动物模型的建立 |
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| 引用本文： | 李文荟,周磊,耿华欧,蔡海燕. 舌癌动物模型的建立[J]. 湛江医学院学报, 2002, 20(2): 85-86 |
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| 作者姓名： | 李文荟 周磊 耿华欧 蔡海燕 |
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| 作者单位： | 广东医学院附属医院 广东湛江524001(李文荟，周磊，耿华欧)，广东医学院附属医院 广东湛江524001(蔡海燕) |
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| 摘 要： | 目的：为研究舌鳞状细胞癌(SCC)的发生和发展规律建立舌鳞癌动物模型。方法：采用化学致癌剂4—硝基喹啉—l—氧化物(NQO)给水饮用法．对20只SD大白鼠舌粘膜进行诱癌实验、观察肿瘤诱发情况。结果：至32周时、20只大鼠有14只出现高分化鳞状细胞癌、3只为原位癌；余3只为轻、中度异常增生。结论：以饮水给4NQO能成功地建立舌癌的动物模型。
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| 关 键 词： | 舌癌 动物模型 4—硝基喹啉—l—氧化物 诱癌实验 |
| 文章编号： | 1005-4057(2002)-02-0085-02 |
| 修稿时间： | 2001-07-04 |
A rat model of tongue squamous cell carcinoma induced by 4-nitroquineline-1-oxide |
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| Li Wen hue,ZHOU Lei,GENG Hua ou,et al. A rat model of tongue squamous cell carcinoma induced by 4-nitroquineline-1-oxide[J]. Journal of Guangdong Medical College, 2002, 20(2): 85-86 |
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| Authors: | Li Wen hue ZHOU Lei GENG Hua ou et al |
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| Abstract: | Objective: To establish an animal model of tongue squamous cell carcinoma (SCC) for further study of tongue carcinogenesis Methods: SD rats drank 4 nitroquinoline 1 oxide(4 NQO) solution every day Rats were killed in 32 weeks,and their tongues were removed for histopathological examination Results: In 20 rats treated with 4 NQO,there were 14 rats with high differentiated SCC of tongue,3 with carcinoma in situ,and 3 with mild to moderate dysplasia Conclusion: 4 NQO could reliably induce neoplastic lesions in rat tongue mucosae which mimic human oral carcinoma or precancerous lesions in morphological and histological characteristics |
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| Keywords: | a nimal model 4 nitroquinoline 1 oxide rat tongue carcinoma |
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