Presence of virus particles in neural cells of goats with caprine arthritis encephalitis

The possible neurotropism of ungulate lentivirus was examined in clinical cases. Brain and ganglion tissue samples were examined from six female goats with caprine arthritis encephalitis and from six healthy controls. Ultrastructural examination revealed typical cytoplasmic A type retrovirus particles in the neural tissue of the diseased does. None were seen in the respective controls. Furthermore, no budding or extracellular retrovirus particles were seen in any of the neural tissue samples examined.