The untold story between enhancers and skeletal muscle development |
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| Authors: | ZHANG Yong-sheng LU Dan LIU Yu-wen YI Guo-qiang TANG Zhong-lin |
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| Affiliation: | 1. Shenzhen Branch Guangdong Laboratory for Lingnan Modern Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518124, P.R.China;2. College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, P.R.China;3. Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518124, P.R.China;4. State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, P.R.China |
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| Abstract: | Currently, enhancers have key transcriptional regulatory roles in muscle development. Skeletal muscle formation involves various molecules, and in animals, enhancers are one of the main types of transcriptional regulatory regions that are of great importance to regulate myogenic gene expression. In muscle development, enhancers can generate enhancer RNAs(eRNAs) that are involved in the regulation of gene transcription. The regulation of gene expression by eRNAs offers great potential in improving animal production traits. Herein we comprehensively review the roles of enhancers in muscle formation and its potential function in skeletal muscle development. This review will describe the future application of enhancers in skeletal muscle development and discuss the prospects that enhancer studies offer for agriculture, biotechnology, and animal breeding. |
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| Keywords: | animal enhancer eRNA skeletal muscle growth and development |
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