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Liquid chromatographic determination of miconazole nitrate in creams and suppositories
Authors:T A Tyler  J A Genzale
Institution:Herbert V. Shuster, Inc., Quincy, MA 02171.
Abstract:A rapid method has been developed for the determination of miconazole nitrate in creams and suppositories. The sample is dissolved in ethanol, diluted in acetonitrile-water (1 + 1), and injected onto a C18 column. The mobile phase consists of 55% acetonitrile, a triethylammonium phosphate buffer, and an ion-pairing agent. The total run time is less than 4 min, and the active ingredient is determined using absorbance detection at 214 nm. The mean recovery of miconazole from spiked placebo samples was 99.7 +/- 0.7% for the cream samples at the 2% level and 98.8 +/- 0.3% for the suppository samples at the 4% level.
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