Z0206细菌富硒多糖对小鼠的免疫调节作用研究

本试验通过建立环磷酰胺（CP）诱导的免疫抑制小鼠模型，研究了Z0206细菌富硒多糖的免疫调节功能。试验分为四个处理：Ⅰ组为对照组；Ⅱ组为CP组；Ⅲ组为细菌富硒多糖组；Ⅳ组为细菌富硒多糖预防组。结果表明，与对照组相比，细菌富硒多糖组小鼠免疫器官指数、NK细胞活性、血液溶血素水平（HC50）和脾细胞抗体形成数（PFC）均显著提高（p<0.05），T细胞亚群增殖有所提高，但差异不显著（p>0.05）。与CP组相比，细菌富硒多糖预防组能使CP诱导的免疫抑制得到修复，改善试验小鼠免疫器官指数、T淋巴细胞和自然杀伤细胞（NK）活性、血液溶血素水平和脾细胞抗体形成数，差异显著（p<0.05）。提示：细菌富硒多糖能增强小鼠的免疫功能，对CP诱导的免疫抑制具有修复作用。

Immunoregulatory Effect of the Enriched-selenium Polysaccharide Z0206 on Mice

Based on the cyclophosphamide (CP) induced immunosuppressed mice model, we investigated the effect of the enriched-selenium polysaccharide produced by Z0206 on the immunoloregulation in mice. The mice were divided into 4 groups, control groupⅠ, CP group Ⅱ, enriched-selenium polysaccharide group Ⅲ and prevetion of enriched-selenium polysaccharide group Ⅳ. They were given different doseages of normal saline or the enriched-selenium polysaccharide Z0206 by gavage respectively. Compared to the control group, immunosuppression appeared in the CP group. Results showed that compared with the CP group, the enriched-selenium polysacchride Z0206 could remission the immunosuppression, enhanced the spleen and thymus index(p<0.05), regulated T cell subsets(p>0.05), enhanced the NK cell activities(p<0.05), raised the plapue forming cell assay and hemolysin level in mice (p<0.05). However, compared with the control group, the spleen and thymus index, T cell subsets, NK activity, and humoral immunity increased significantly(p<0.05). Conclusion: the enriched-selenium have obvious improvement and arrest of immunosuppression induced by CP in mice.