线粒体膜通透性变化与细胞凋亡的关系

线粒体膜通透性转换孔是一种位于线粒体内膜的非选择性孔道，它的开放引起线粒体膜通透性改变，导致细胞色素C、凋亡诱导因子和Ca²⁺及膜间隙中的胱冬肽酶原等凋亡因子释放到细胞质中，致使细胞整体结构破坏、功能紊乱，发生凋亡。以前普遍认为线粒体膜通透性改变(mitochondrial permeability transition，MPT）是导致细胞凋亡的关键点，但一些新的研究结果表明，MPT与细胞凋亡并不存在必然的联系。作者结合细胞凋亡方面的研究着重就线粒体膜通透性转换的生物学功能和腺嘌呤核苷酸转位子、环孢素A 结合蛋白D及Bcl-2家族蛋白定位、转位在通透性转换中的作用及其与细胞凋亡的关系进行概括性论述与分析。

Relationship of Mitochondrial Permeability Transition with Cell Apoptosis

Mitochondrial permeability transition pore(MPTP) is a non-selective inner membrane channel located in mitochondrion.MPTP triggers mitochondrial permeability transition,resulting in the release of apoptotic factor,for example cytochrome C,apoptosis inducing factor(AIF),Ca2 and procaspase,cell structure destroyed and function disordered,finally apoptosis.Formerly,MPT is considered the key for cell apoptosis,but the recent research show there is no evitable relationship.The review focuses on the biological function of MPT,adenine nucleotide translocatar(ANT),Cyp D and the relationship of orientation,distribution of Bcl-2 family with MPT.