Cross-neutralizing and subclass characteristics of antibody from horses with equine infectious anemia virus |
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| Authors: | K I O'Rourke L E Perryman T C McGuire |
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| Institution: | Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164. |
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| Abstract: | Antibody responses in horses with equine infectious anemia virus (EIAV) were examined to determine their cross-neutralizing capacity. Antibodies induced by infection with any of six biologically cloned variants of EIAV cross-neutralized multiple variants from the group. Anti-EIAV antibody was found in both the IgG and IgG(T) subclasses in plasmas with virus-neutralizing activity and the majority of antiviral antibody was of the IgG(T) subclass. Depletion of IgG(T) did not increase the neutralization indexes of either neutralizing or non-neutralizing plasma samples. |
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