| MicroRNA调控抗病毒免疫和病毒复制 |
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| 引用本文： | 王岚,何明宇,张敏,丁军涛. MicroRNA调控抗病毒免疫和病毒复制[J]. 畜牧兽医学报, 2023, 54(2): 463-472. DOI: 10.11843/j.issn.0366-6964.2023.02.005 |
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| 作者姓名： | 王岚 何明宇 张敏 丁军涛 |
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| 作者单位： | 1. 新疆大学生命科学与技术学院, 乌鲁木齐 830046;2. 新疆生物资源基因工程重点实验室, 乌鲁木齐 830046 |
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| 基金项目： | 新疆维吾尔自治区自然科学基金面上项目（2016D01C041） |
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| 摘 要： | MicroRNA （miRNA）是一类高度保守的内源性非编码单链小RNA分子,长度约为19~25 nt,通常在基因表达的转录后水平起调控作用,参与细胞发育、增殖、凋亡、免疫等多种生命活动。大量的研究表明,多种miRNAs通过直接或间接的方法在病毒感染期间调节病毒复制、细胞增殖或凋亡以及肿瘤发育等生物反应。本文主要对病毒感染期间miRNA在免疫反应、病毒复制中的调控机制进行综述,旨在为miRNA的开发应用和抗病毒相关治疗策略提供参考。
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| 关 键 词： | microRNA 病毒感染 病毒复制 免疫调控 |
| 收稿时间： | 2022-02-22 |
MicroRNAs Regulate Antiviral Immunity and Viral Replication |
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| WANG Lan,HE Mingyu,ZHANG Min,DING Juntao. MicroRNAs Regulate Antiviral Immunity and Viral Replication[J]. Chinese Journal of Animal and Veterinary Sciences, 2023, 54(2): 463-472. DOI: 10.11843/j.issn.0366-6964.2023.02.005 |
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| Authors: | WANG Lan HE Mingyu ZHANG Min DING Juntao |
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| Affiliation: | 1. College of Life Science and Technology, Xinjiang University, Urumqi 830046, China;2. Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, Urumqi 830046, China |
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| Abstract: | MicroRNA(miRNA) is a class of highly conserved endogenous non-coding single-stranded small RNA molecules, about 19~25 nt in length, which usually plays a regulatory role in the post-transcriptional level of gene expression and participates in a variety of life activities such as cell development, proliferation, apoptosis and immunity. A large number of studies have shown that a variety of miRNAs regulate viral replication, cell proliferation or apoptosis and tumor development during viral infection through direct or indirect methods. This paper mainly reviews the regulatory mechanism of miRNA in immune response and viral replication during viral infection, aiming to provide reference for the development and application of miRNA and antiviral related treatment strategies. |
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| Keywords: | microRNA viral infection viral replication immune regulation |
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