Comparison of fine-scale recombination rates in humans and chimpanzees |
| |
Authors: | Winckler Wendy Myers Simon R Richter Daniel J Onofrio Robert C McDonald Gavin J Bontrop Ronald E McVean Gilean A T Gabriel Stacey B Reich David Donnelly Peter Altshuler David |
| |
Institution: | Department of Molecular Biology and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114-2622, USA. |
| |
Abstract: | We compared fine-scale recombination rates at orthologous loci in humans and chimpanzees by analyzing polymorphism data in both species. Strong statistical evidence for hotspots of recombination was obtained in both species. Despite approximately 99% identity at the level of DNA sequence, however, recombination hotspots were found rarely (if at all) at the same positions in the two species, and no correlation was observed in estimates of fine-scale recombination rates. Thus, local patterns of recombination rate have evolved rapidly, in a manner disproportionate to the change in DNA sequence. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|