In vitro effects of cyclopiazonic acid mycotoxin on turkey papillary muscles |
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| Authors: | C D Miller J L Richard F B Hembrough G D Osweiler D F Cox |
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| Affiliation: | USDA, Agricultural Research Service, National Animal Disease Center, Ames, IA 50010. |
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| Abstract: | An in vitro bioassay system was used to study the effects of cyclopiazonic acid (CPA) mycotoxin on cardiac muscle. Acute exposure to 6 micrograms of CPA/ml of modified Krebs-Henseleit solution significantly (P less than 0.05) decreased 5 in vitro turkey cardiac muscle performance criteria: maximal weight a muscle could lift; maximal contraction velocity; relaxation velocity; time to peak contraction; and total time for muscle contraction and relaxation. The effect on these 5 criteria appeared to result from intracellular changes partially associated with calcium availability and were irreversible, suggesting that physiologic changes had developed after acute exposure to CPA. |
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