| 氟哌酸在鸡体内的代谢动力学观测 |
| |
| 引用本文： | 王笃学,阴天榜,崔耀明,赵海军.氟哌酸在鸡体内的代谢动力学观测[J].郑州牧业工程高等专科学校学报,1993(3). |
| |
| 作者姓名： | 王笃学 阴天榜 崔耀明 赵海军 |
| |
| 作者单位： | 郑州牧专医药系
(王笃学，阴天榜，崔耀明)，郑州牧专医药系(赵海军) |
| |
| 摘 要： | 采用高效液相色谱法,测定了鸡静脉注射氟哌酸10,20,40mg/kg三个剂量的血药浓度,并经计算处理,符合二室开放模型,给出了药代动力学参数。其T1/2β分别为2.37,4.73,4.465h,未见明显差异。AUC随剂量增大而增加,分别为12.03,44.82,60.87μg·ml/h。
|
| 关 键 词： | 氟哌酸 鸡 药物代谢动力学 |
THE PHARMACOKINETICS OF NORFLOXACIN IN CHICKS |
| |
| Wang Duxue et al.THE PHARMACOKINETICS OF NORFLOXACIN IN CHICKS[J].Journal of Zhengzhou College of Animal Husbandry Engineering,1993(3). |
| |
| Authors: | Wang Duxue |
| |
| Institution: | Wang Duxue et al |
| |
| Abstract: | This paper reported the Chick plasma concentration detemin-ation affer iv doses of nofloxacin for 10,20 and 40mg/kgb wt assay with HPLC. It was two-compartement model,the pharmacokinetic parameters were obtained.The were no obvious difference amongthe T1/2J3,they were 2.37,4.73 and 4.65h,respectively .AUC were increased in proportion to the doses,the were 12.03,44.82 and 60.87 ug.h/L for the doses of 10,20 and 40.mg/kgb. wto respectively. |
| |
| Keywords: | Norfloxacin Chick pharmacokinctic |
| 本文献已被 CNKI 等数据库收录！ |
|
