Screening of some rare endemic Italian plants for inhibitory activity on 5-lipoxygenase |
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Authors: | Prieto José-María Bader Ammar Martini Francesca Ríos José-Luis Morelli Ivano |
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Affiliation: | Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Av. Vicent Andrés Estellés, s/n. 46100 Burjassot, Valencia, Spain. |
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Abstract: | The extracts of four rare plants found on the islands of Sicily, Vulcano and Marettimo, Southern Italy, were screened for their inhibitory effect on the production of leukotriene B4 by 5-lipoxygenase in intact cells. The methanol extracts of pods of Cytisus aeolicus and aerial parts of Thymus richardii were the most active extracts, inhibiting almost completely the leukotriene B4 production at 200 and 50 microg/ml, respectively. |
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Keywords: | Cytisus aeolicus Thymus richardii 5-Lipoxygenase Leukotriene B4 Cytotoxicity |
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