Fascin‐1 expression in canine cutaneous and oral melanocytic tumours |
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| Authors: | N Yamada T Mori M Murakami S Noguchi H Sakai Y Akao K Maruo |
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| Institution: | 1. United Graduate School of Veterinary Sciences, Gifu University, Yanagido, Gifu, Japan;2. Department of Veterinary Clinical Oncology, Faculty of Applied Biological Sciences, Gifu University, Yanagido, Gifu, Japan;3. Comparative Cancer Centre, Gifu University, Yanagido, Gifu, Japan;4. Department of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, Yanagido, Gifu, Japan;5. United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Yanagido, Gifu, Japan |
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| Abstract: | Fascin‐1 expression was examined in 9 cutaneous melanocytomas and 47 oral melanomas. The cases were scored on the basis of extent and intensity of staining, and combined scores were calculated. Fascin‐1 expression was observed in 5/9 (56%) melanocytomas and 46/47 (98%) melanomas. The combined score for fascin‐1 was significantly greater in stage III/IV melanomas than in stage I/II melanomas (P < 0.05). In addition, strong fascin‐1 staining was associated with a significantly shortened survival time (P < 0.05). The results of this study suggest that fascin‐1 overexpression correlates with the malignancy of canine melanoma and has the potential to be a new immunohistochemical marker to predict the clinical course of canine melanoma. In addition, targeted therapy for fascin‐1 may represent a new strategy for the treatment of canine melanoma. |
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| Keywords: | canine fascin‐1 immunohistochemistry invasion melanoma metastasis |
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