EFFECT OF SODIUM DIATRIZOATE ON THE IN VITRO GROWTH OF THREE COMMON CANINE URINARY BACTERIAL SPECIES |
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Authors: | Annette L. Ruby BA Gerald V. Ling DVM Norman Ackerman DVM |
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Affiliation: | Department of Medicine, School of Veterinary Medicine, University of California, Davis, California 95616.;Department of Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California 95616. |
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Abstract: | The mean concentration of diatrizoate in urine specimens of eight dogs collected 20 minutes after intravenous injection of 2.2 ml/kg of sodium and meglumine diatrizoate (iodine concentration, 288 mg/ml) was 80 mg/ml (iodine concentration, 48 mg/ml). The mean concentration plus 1 SD was 111 mg/ml (iodine concentration, 66 mg/ml), and the mean concentration plus 2 SD was 142 mg/ml (iodine concentration, 85 mg/ml). The presence of diatrizoate at a concentration of 142 mg/ml did not inhibit in vitro bacterial growth of any of ten randomly selected canine urinary isolates of Escherichia coli or any of ten randomly selected urinary isolates of Staphylococcus aureus. In vitro bacterial growth of all ten randomly selected urinary bacterial isolates of Proteus mirabilis was significantly inhibited by a diatrizoate concentration of 80 mg/ml. Bacterial growth was progressively inhibited by increased diatrizoate concentrations. |
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Keywords: | diatrizoate canine urinary bacteria bactericidal effect |
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