DDT and sodium transport in the eel electroplaque |
| |
Authors: | William D Niemi George D Webb |
| |
Institution: | Department of Physiology & Biophysics, University of Vermont College of Medicine, Given Medical Building, Burlington, Vermont 05405 USA |
| |
Abstract: | DDT inhibits the ATPase activity of the intact eel electroplaque. At a concentration of 10?5M, DDT inhibited 46% of the total ATPase activity, and 10?4M DDT inhibited 62% of the total ATPase activity and 62% of the ouabain-sensitive ATPase activity. The latter concentration of DDT reduced the rate of Na efflux from intact electroplaques and slowed the rate of recovery of the membrane potential following a large depolarization produced by carbamylcholine application. Repetitive direct stimulation of the innervated membrane at 10 Hz during the application of 10?4M DDT produced a significant irreversible depolarization. Ouabain, 10?4M, produced similar effects. The possible role of the inhibition of active NaK transport in producing the symptoms of DDT poisoning is discussed. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|