Deuterium isotope effects on the formation of mercapturic acids from lindane in rats |
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Authors: | Norio Kurihara Tetsuya Suzuki Minoru Nakajima |
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Institution: | 1. Radioisotope Research Center, Kyoto University, Kyoto 606, Japan;2. Research Institute for Food Science, Kyoto University, Kyoto 606, Japan;3. Department of Agricultural Chemistry, Kyoto University, Kyoto 606, Japan |
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Abstract: | Metabolism experiments with rats showed that significant isotope effects () were associated with the in vivo formation of dichloro and trichlorophenylmercapturic acids from a 1:1 mixture of normal and hexadeuterated lindane. This is evidence that rate-determining dehydrogenation and dehydrochlorination, both of which proceed with significant isotope effects, are essential in the pathway of dichloro- and trichlorophenylmercapturic acid formation from lindane. No significant primary isotope effects were associated () with the formation of monochlorophenylmercapturic acid. This suggests that the 1,2-dechlorination to tetrachlorocyclohexene followed by glutathione conjugation is the probable pathway that produces this metabolite from lindane. |
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Keywords: | To whom correspondence and reprint requests should be addressed at the Radioisotope Research Center Kyoto University |
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