EFFECTS OF METRIZAMIDE MYELOGRAPHY ON CEREBROSPINAL FLUID ANALYSIS IN THE DOG |
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| Authors: | Michael C Carakostas DVM PhD Kent A Gossett DVM MS PhD John W Watters DVM MS Peter S MacWilliams DVM PhD |
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| Institution: | Department of Veterinary Pathology, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803;Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana 70803 |
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| Abstract: | The effect of metrizamide myelography on the composition of cerebrospinal fluid (CSF) was studied. Seven dogs received an intracisternal injection of metrizamide. An intracisternal puncture was performed in three additional dogs that did not receive metrizamide. CSF was collected before myelography and 24, 72, and 144 hours after myelography from all dogs. A significant increase in the percentage of neutrophils (p<0.05) and a pleocytosis noted 24 hours after myelography (p<0.02) were attributed to the effect of metrizamide. Significant increases in total protein concentration (p<0.001) and erythrocyte count (p<0.05), and a decrease in the percentage of small mononuclear cells (p<0.01) were attributed to repeated intracisternal puncture. No significant changes were observed for CSF creatine phosphokinase activity or the percentage of large mononuclear cells. |
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| Keywords: | cerebrospinal fluid cytology dog metrizamide myelography |
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