A genetic variant near the equine interleukin 6 gene associated with copper:zinc ratio |
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| Authors: | Beghelli Daniela Giacconi Robertina Mocchegiani Eugenio Cipriano Catia Malavolta Marco Renieri Carlo |
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| Affiliation: | School of Environmental Sciences, University of Camerino, Camerino, Italy. daniela.beghelli@unicam.it |
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| Abstract: | The aim of this study was to validate an A/T single nucleotide polymorphism (SNP) corresponding to a LINE2 sequence located ～1.1kb downstream of the IL-6 gene (SNP BIEC2-911738) and to determine if this variant is correlated with interleukin 6 (IL-6) modulation or with different plasma concentrations of Zn, Cu, Se and Fe. The frequency of the newly described variant T ranged from 0 to 23.1% among different breeds of horses. SBIEC2-911738 was not associated with changes in IL-6 plasma levels. Increased Cu:Zn ratios were observed in horses carrying the AT genotype independently of breed when stabled for 24h after physical exercise. |
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