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Colostral immunoglobulin-A: synthesis in vitro of T-chain by rabbit mammary gland
Authors:R Asofsky  P A Small
Abstract:When minced mammary tissue from lactating rabbits was incubated in vitro with C(14)-labeled lysine and isoleucine, it incorporated radio-activity into colostral immunoglobulin A. The only portion of this colostral molecule with significant labeling was T-chain, with little or no labeling of light or heavy chains. It was thus demonstrated that T-chains are synthesized by mammary gland. Because the remainder of the molecule was derived from unlabeled material, in vivo it was probably derived from serum.
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