感染IBDV的雏鸡在接种传染性支气管炎疫苗后免疫器官的免疫细胞变化

１２０只无ＩＢＤＶ母源抗体的雏鸡随机分成４个实验组和４个对照组，分别于第１、２、３、４周龄时感染ＩＢＤＶ，或用灭菌生理盐水作对照感染，以后分２次用传染性支气管炎疫苗进行免疫。结果发现，首次免疫后第１４ｄ，法氏囊、胸腺和脾脏中的浆细胞、ＴＡＮＡＥ＋及淋巴细胞数均明显低于对照组；二次免疫后第１４ｄ各指标虽有所升高，但仍低于二次免疫对照组。表明感染ＩＢＤＶ的雏鸡对传染性支气管炎疫苗的首次免疫呈严重的抑制状态，而对二次免疫仅有轻微抑制作用；同时证明，ＩＢＤＶ在引起体液免疫抑制的同时还能引起细胞免疫抑制，而且感染日龄越小，免疫抑制就越严重。

The Immune Change In the Bursa of fabricius Spleen and Thymus of the IBDV INFECTED Baby Chicks With the Vaccination of IBV

Two experiments were carried out on the IBDV infected baby chicks with the vaccination of IBV. The criteria for both the two experiments included the population of T ANAE + and plasma cell in the bursa of Fabricius, spleen and thymus. The first experiment was ended at the 14th day after the first vaccination, while the second one was recorded with same interval after the second vaccination. The record from the first experiment as a whole was found much less than that of the control ( P <0.01). It turned out that the earlier the chicks were infected with IBDV, the more significant the difference was. As to the second experiment, increase of all the in dics was registered, yet the were found significantly lower than that of the control ( P <0.05). The author came to the conclusion that the baby chicks exposed to the first vaccination were au put into a state on immunosuppression. However, only slight effect was revealed in the case of those chicks exposed to the second injection. It appeared that the younger the IBDV infected chicks were, the more severe the immunosuppression would be.