替米考星对畜禽常见病原菌体外抑菌活性的研究

采用试管2倍稀释法对国产替米考星与头孢唑林钠进行了畜禽常见的18种病原菌体外抑菌活性比较试验.结果表明,替米考星对革兰氏阳性茵及某些阴性茵、鸡败血支原体等均有良好的抑制作用,对部分病原茵如对李氏杆菌、禽巴氏杆茵、猪丹毒杆菌、金黄色葡萄球菌、肺炎链球菌、支气管炎博德特氏茵、猪胸膜肺炎放线杆菌、副溶血嗜血杆菌、鸡败血支原体等高度敏感,表现为具有比头孢唑林钠更强的抑菌活性,但对部分肠道致病菌如大肠杆菌、绿脓杆菌、沙门氏茵等表现为中敏或抗药,抑茵效果与头孢唑林钠相当或较差.

Study on bactriostatic effets of Tilmicosion on some commonly pathogenic bacteria of domestic animals in vitro

The comparative activity against 18 bacteria of tilmicosin and cephazolin-Nawas was carried out with double dilution method in vitro. The results showed that tilmicosin inhibits efficiently Gram-positive bacteria and some Gram-negative bacteria, Mycoplasmagallisepticum, et al. some pathogenic organisms such as Listeria monocytogenes, Pasteurella aviseptica, Erysipelothrix rhusiopathiae, staphylococcus aureus, streptococcus pneumoniae,Bordetella bronchiseptica, Actinobacillus pleuropneumoniae, Haemophilus parahaemolyticus, Mycoplasma gallisepticum are more susceptible to tilmicosin than cephazolin-Na. However, some pathogenic bacteria in intestinal such as enterosch erichia coli,Bacillus pyocyaneus, salmonella are less susceptible to tilmicosin than cephazolin-Na.