Kidney transplantation in dogs with naturally occurring end-stage renal disease |
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Authors: | Mathews K A Holmberg D L Miller C W |
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Institution: | Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Canada. |
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Abstract: | Renal allografts were performed between unrelated donors and 15 dogs with naturally occurring end-stage renal disease. Donor selection was based on compatible dog erythrocyte antigen typing and cross-matching. An immunosuppressive protocol consisting of rabbit antidog antithymocyte serum, cyclosporin-A, azathioprine, and prednisone was used to control postoperative rejection of the donated kidney. Although seven animals died because of technical failures or rejection episodes, a median survival time of eight months has been achieved, with two dogs living for longer than five years after surgery. Long-term survivors have died from a variety of problems not related to renal allograft rejection. |
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