| 七种常用渔药及组合对罗非鱼致病性海豚链球菌的抗菌试验 |
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| 引用本文： | 张彬,黄婷,陈福艳,陈明,余晓丽,梁万文. 七种常用渔药及组合对罗非鱼致病性海豚链球菌的抗菌试验[J]. 中国兽药杂志, 2011, 45(3) |
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| 作者姓名： | 张彬 黄婷 陈福艳 陈明 余晓丽 梁万文 |
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| 作者单位： | 广西水产研究所鱼病研究室,南宁,530021 |
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| 基金项目： | 国家科技支撑计划项目，广西科学研究与技术开发计划项目 |
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| 摘 要： | 探讨了7种常用抗菌渔药对罗非鱼致病性海豚链球菌的体内外抗菌作用.采用二倍稀释法测定了7种渔药对致病菌的最低抑菌浓度(MIC)和最低杀菌浓度(MBC);在初筛基础上以MIC为单位,1×MIC、5×MIC、10×MIC和20×MIC下平板抑菌圈直径为参数,分别比较所筛选5种药物抗菌效果并优化最佳参数;利用优化的最佳参数比较5种药物单独用药与联合用药对海豚链球菌的抑菌效果;并通过拌饵投喂给药方式对罗非鱼进行5种药物治疗性给药试验.结果表明,抗菌先锋对海豚链球菌的MIC和MBC最小,分别为6.4、12.8μg/mL,其次是伯乐立康,均为12.8μg/mL;而鱼康和肠炎烂鳃灵即使在1638.4μg/mL下也无抗菌效果.5倍MIC下抑菌圈直径为本试验筛选抗菌药物的最佳参数.5MIC时,海豚链球菌对伯乐立康和抗菌先锋敏感,对菌必清、菌毒康和海鱼安中度敏感.菌毒康与海鱼安的联合抗菌效果最佳.鱼体内抗菌试验结果表明,抗菌先锋和伯乐立康的治疗有效率超过75%,达到了理想的治疗效果,是防治罗非鱼海豚链球菌病的首选药物.
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| 关 键 词： | 罗非鱼 海豚链球菌 渔用药物 最低抑菌浓度 |
The Antibacterial Test of Seven Kind Common Fishery Drugs and Their Combinations against Pathogenic Streptococcus iniae from Tilapia |
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| ZHANG Bin,HUANG Ting,CHEN Fu-yan,CHEN Ming,YU Xiao-li,LIANG Wan-wen. The Antibacterial Test of Seven Kind Common Fishery Drugs and Their Combinations against Pathogenic Streptococcus iniae from Tilapia[J]. Chinese Journal of Veterinary Drug, 2011, 45(3) |
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| Authors: | ZHANG Bin HUANG Ting CHEN Fu-yan CHEN Ming YU Xiao-li LIANG Wan-wen |
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| Affiliation: | ZHANG Bin,HUANG Ting,CHEN Fu-yan,CHEN Ming,YU Xiao-li,LIANG Wan-wen (Lab of Fishery Disease,Guangxi Institute of Fisheries,Nanning 530021,China) |
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| Abstract: | Effect of seven common fish drugs on pathogenic Streptococcus iniae of tilapia in vivo and vitro was investigated in this study.The minimum inhibitory concentrations(MIC) and the minimum bactericidal concentrations(MBC) of seven fish drugs were tested by the method of doubling dilution.According to the preliminary screening,comparing the inhibiting and bactericidal effects of 5 fish drugs on Streptococcus iniae respectively,the best parameter was obtained.Then,the best parameter was used to test the inhibit... |
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| Keywords: | tilapia Streptococcus iniae fishery drugs MIC |
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