柴芪颗粒抗菌及保肝作用研究

为探讨柴芪颗粒的保肝、体外抗菌作用和对小鼠免疫功能的影响,分别采用四氯化碳(CCl4)和D 氨基半乳糖(D GalN)诱导的小鼠肝损伤模型,给予不同剂量的柴芪颗粒(15、10、5 g/kg体重),测定血清中谷丙转氨酶(ALT)、谷草转氨酶(AST)的活性和肝组织谷胱甘肽(GSH)的含量。研究表明柴芪颗粒对四氯化碳(CCl4 )及D 氨基半乳糖(D GalN)所引起的小鼠肝损害有明显的保护作用,对血清ALT、AST活性升高有明显的降低作用(P<0.01),减少了CCl4 肝损伤小鼠戊巴比妥钠的睡眠时间;并能明显提高小鼠网状内皮系统的吞噬功能,体外试验有一定抑菌作用。可见柴芪颗粒具有抗菌、保肝和提高免疫功能的作用。

Effects of CQKL on Liver Protection, Antibacterial Action and Immunity Function in Mice

In order to study the effects of Chaiqikeli (CQKL) on liver protection, antibacterial action and immunity function, hepatic injury models were established by injecting carbon tetrachloride (CCl_4)and D-galactosamine (D-GalN)into mouse and then the different dose of CQKL were given respectively. The activity of ALT and AST in the serum, the contents of glutathione (GSH) in liver homogenate from all mouse were determined. It is suggested that CQKL could significantly protect liver from CCl_4 and D-GalN injury, lower the activity of enzyme ALT, AST in serum, shorten the sleep duration induced by embuter in CCl_4 damaged mice,improve the phagocytic function of reticuloendothelial system in mice and inhibit bacterial in vitro. CQKL have the antibacterial,liver protection and immunological enhancement effects.