Pharmacokinetics and metabolism of sulphadimidine in kids at 12 and 18 weeks of age |
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| Authors: | J F M NOUWS A DJ WATSON† A SJ P A M VAN MIERT† M DEGEN H VAN GOGH† T B VREE‡ |
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| Institution: | Department of Veterinary Pharmacology, Pharmacy and Toxicology, Utrecht, The Netherlands. |
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| Abstract: | The pharmacokinetics and metabolism of sulphadimidine (SDM) following intravenous administration of 100 mg/kg were studied in seven dwarf preruminant kids at 12 weeks of age, and again at the ruminant stage, when the animals were 18 weeks old. The persistence of SDM in 18-week-old kids was prolonged in comparison to the 12-week-old animals: a lower total body clearance and a prolonged elimination of SDM were obtained in the older animals. The renal clearance values of SDM and its metabolites were the same at both ages. The decrease of SDM clearance is related to the significant reduction in SDM hydroxylation at the older age. The reduced oxidative hepatic metabolism may result from the sexual maturation of the kids. |
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