The effects of antigenic competition on the efficacy of multivalent footrot vaccines |
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| Authors: | CL SCHWARTZKOFF,JR EGERTON&dagger ,DJ STEWART&Dagger ,PR LEHRBACH§ ,TC ELLEMAN¶ ,PA HOYNE¶ |
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| Affiliation: | *Arthur Webster Pty Ltd, PO Box 234, Baulkham Hills, New South Wales 2153;†Department of Animal Health, University of Sydney, Private Bag 3, Camden, New South Wales 2570;‡Division of Animal Health, CSIRO, Private Bag No 1, Parkville, Victoria 3052;§Biotech Australia Pty Ltd, PO Box 20, Roseville, New South Wales 2069;¶Division of Biomolecular Engineering, CSIRO, Royal Parade, Parkville, Victoria 3052 |
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| Abstract: | SUMMARY A multivalent footrot vaccine has been developed, containing pilus antigens produced in recombinant Pseudomonas aeruginosa and representing all nine serogroups of Dichelobacter (Bacteroides) nodosus commonly recognised in the field. The responses of sheep to the multivalent vaccine have been compared with those to monovalent vaccines representing only a single serogroup. Antigenie competition between serogroups occurred in sheep immunised with the multivalent formulation, but high levels of protection were still achieved. The study showed that in multivalent footrot vaccines, antigenic competition is predominantly due to the presence of a family of immunologically-related pilus antigens rather than to interference by extraneous proteins. |
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