| 单剂量口灌阿维菌素在草鱼体内的药动学及残留研究 |
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| 引用本文： | 秦改晓,徐文彦,艾晓辉,唐国盘,崔锦,李向辉,袁科平.单剂量口灌阿维菌素在草鱼体内的药动学及残留研究[J].淡水渔业,2012(4):47-52. |
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| 作者姓名： | 秦改晓 徐文彦 艾晓辉 唐国盘 崔锦 李向辉 袁科平 |
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| 作者单位： | 郑州牧业工程高等专科学校;中国水产科学研究院长江水产研究所 |
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| 基金项目： | “十一五”国家科技支撑计划“渔药安全使用及快速检测技术研究”项目(2006BAD03B04-04) |
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| 摘 要： | 按0.1 mg/kg的剂量给草鱼(Ctenopharyngodon idellus)灌服阿维菌素,用高效液相色谱法检测用药后不同时间的血浆、肌肉和肝脏中的药物浓度,然后用3P97药代动力学软件处理药时数据,对药物在草鱼体内药动学及组织残留进行研究.结果表明:单剂量口灌阿维菌素在草鱼血浆中主要药动学参数为:AUC 1 6...
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| 关 键 词： | 阿维菌素 草鱼(Ctenopharyngodon idellus) 口灌 药动学 残留 |
Studies on the pharmacokinetics and residues of avermectin in grass carp(Ctenopharyngodon idellus) after single oral administration |
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| QIN Gai-xiao,XU Wen-yan,AI Xiao-hui,TANG Guo-pan,CUI Jin,LI Xiang-hui,YUAN Ke-ping.Studies on the pharmacokinetics and residues of avermectin in grass carp(Ctenopharyngodon idellus) after single oral administration[J].Freshwater Fisheries,2012(4):47-52. |
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| Authors: | QIN Gai-xiao XU Wen-yan AI Xiao-hui TANG Guo-pan CUI Jin LI Xiang-hui YUAN Ke-ping |
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| Institution: | 1.Zhengzhou College of Animal Husbandry Engineering,Zhengzhou 450011,China; 2.Yangtze River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Wuhan 430223,China) |
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| Abstract: | A dose(0.1 mg/kg) of avermectin was given to grass carp by oral administration.Tissues(plasma,muscle,Liver) concentration of avermectin were measured by high performance liquid chromatography(HPLC) with fluorescence detector(FD).The plasma concentration-time data was analyzed with 3P97 practical pharmacokinetics software.The results showed that the main parameters in the blood of grass carp were:AUC 1 638.02 μg·h·L-1,Cmax 18.51 μg·L-1,t1/2α 21.77 h,t1/2β218.71 h,Tpeak 24.00 h,k10 0.023 h-1,k12 0.007 3 h-1,k21 0.004 3 h-1.on the fourteen day after dosing,the residues of avermectin in plasma can not be detected,but the depletion of avermectin in muscle and liver need 25 days. |
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| Keywords: | avermectin grass carp(Ctenopharyngodon idellus) oral administration pharmacokinetics residues |
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