啶虫脒/羧甲基壳聚糖-海藻酸钠凝胶球的制备与控制释放性能研究

采用锐孔法,以羧甲基壳聚糖和海藻酸钠为基质材料制备了啶虫脒缓释微胶囊,以微球的药物包封率为制备工艺优化指标,设定反应时间为50 min,通过L16(45)正交实验得出微球的最佳制备工艺条件:温度为40℃,海藻酸钠浓度为3%,氯化钙浓度为5%,乳化剂量为50 mL,啶虫脒与羧甲基壳聚糖质量比为1∶3。所得微球囊心和壁材之间没有化学键合,对啶虫脒的释放有良好的缓释效果。

Preparation and controlled release of crosslinked acetamiprid-loaded carboxymethyl chitosan and sodium alginate gel beads

Suitable sustained-releasing microspheres containing acetamiprid were prepared by using carboxymethyl chitosan and acacia as base materials.The L16(45) orthogonal experimental design using the standard of drug encapsulation as the criteria was used to optimize the preparation procedures of the microspheres with the reaction time being 50 min.The optimum conditions for microspheres preparation were as follows: the temperature of reaction was 40 ℃;the concentration of sodium alginate was 3%;the concentration of calcium chloride was 5 %;the amount of emulsification was 50 mL;the weight ratio of acetamiprid to carboxymethy chitosan was 1∶3.The results showed that there was no chemical interaction between acetamiprid and the carboxymethy chitosan/sodium alginate complex.The drug releasing properties and releasing performances of the acetamiprid microspheres are good.