Emerging roles of presynaptic proteins in Ca++-triggered exocytosis |
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Authors: | Rettig Jens Neher Erwin |
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Affiliation: | Department of Physiology, Saarland University, Homburg, 66421 Germany. jrettig@uniklinik-saarland.de |
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Abstract: | The twinning of techniques from biophysics and molecular biology has led to remarkable progress in understanding the molecular mechanisms of synaptic transmission. Here we review the current picture of Ca++-triggered exocytosis, which has emerged from studies of a simple cellular model, the adrenal chromaffin cell. We discuss the molecular players that have been assigned a specific role in a particular step of this process and give a brief outlook on what these insights might tell us about mechanisms of short-term plasticity at classical synapses. |
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